We define "GSM450730_FIA_plasma__1, GSM450730_FIA_plasma__2, GSM450730_FIA_plasma__3, GSM450730_FIA_plasma__4" as test group, and as "GSM450723_Naive__1, GSM450723_Naive__2, GSM450723_Naive__3, GSM450723_Naive__4" control group.